Thermo Fisher Scientific MAP4K3 Polyclonal Antibody
MAP4K3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot 및 ELISA에 사용 가능. Human, Mouse, Rat 시료에 반응하며, 고순도 Affinity Chromatography로 정제됨. 연구용으로 UV, TNF-α 자극 관련 신호전달 연구에 적합.
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- PA5121091
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 755–894 of human MAP4K3 (NP_003609.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.94 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914663 |
Product Specific Information
- Positive test controls: SW480, MCF7, 293T, HepG2, Mouse brain, Mouse kidney, Mouse lung, Rat heart, Rat brain
- Immunogen sequence:
ETVNPNSTSS WFTESDTPQT NVTHVTQLER DTILVCLDCC IKIVNLQGRL KSSRKLSSEL TFDFQIESIV CLQDSVLAFW KHGMQGRSFR SNEVTQEISD STRIFRLLGS DRVVVLESRP TDNPTANSNL YILAGHENSY
Target Information
MAP4K3 (also known as GLK) is a member of the STE20 family of serine/threonine protein kinases with an N-terminal catalytic domain and a C-terminal regulatory domain. It acts upstream of MEKK1 and is stimulated by UV radiation and TNF-alpha, leading to activation of the JNK signaling pathway.
MAP4K3 can directly activate PKC-θ during TCR signaling, and elevated MAP4K3 expression has been observed in T cells from patients with systemic lupus erythematosus. It functions as a pro-apoptotic kinase by activating BAX through modulation of PUMA, BAD, and BIM. The kinase activity is stimulated by UV radiation and TNF-alpha and specifically activates the c-Jun N-terminal kinase (JNK) pathway.
Previously known as RAB8-interacting protein-like 1 (RAB8IPL1), MAP4K3 has been renamed mitogen-activated protein kinase kinase kinase 3 (MAP4K3).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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