Thermo Fisher Scientific Human TBK1 Synthetic Peptide
인간 TBK1 단백질의 C-말단 16개 아미노산 서열에 해당하는 합성 펩타이드. TBK1 항체(PA5-19968)의 블로킹 펩타이드로 사용 가능. NF-κB 및 IRF3 신호전달 연구용. PBS(pH 7.2), 0.1% BSA, 0.02% sodium azide 함유.
- 카탈로그번호
- PEP0093
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 16 amino acids near the carboxy terminus of human NAK/TBK1.
PEP-0093 can be used as a blocking peptide with polyclonal antibody PA5-19968.
Target Information
TBK1 (TANK-binding kinase 1) is a serine/threonine kinase belonging to the IKK family, involved in NF-κB activation and IRF3 signaling.
It acts as an essential mediator of gene expression during immune and inflammatory responses. NF-κB regulates numerous genes in response to extracellular stimuli and is inhibited in the cytoplasm by IKB proteins. Phosphorylation of IKB by the IKK complex leads to its degradation and subsequent NF-κB activation.
The IKK complex includes IKKa, IKKβ, and IKKK. TBK1 (also known as NAK or T2K) directly phosphorylates and activates IKKβ, mediating NF-κB activation in response to growth factors and PMA. TBK1 functions upstream of NIK and the IKK complex and plays a critical role in protecting embryonic liver from apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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