Thermo Fisher Scientific Human TBK1 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 16 amino acids near the carboxy terminus of human NAK/TBK1.
PEP-0093 can be used as a blocking peptide with polyclonal antibody PA5-19968.

Target Information

TBK1 (TANK-binding kinase 1) is a serine/threonine kinase belonging to the IKK family, involved in NF-κB activation and IRF3 signaling.
It acts as an essential mediator of gene expression during immune and inflammatory responses. NF-κB regulates numerous genes in response to extracellular stimuli and is inhibited in the cytoplasm by IKB proteins. Phosphorylation of IKB by the IKK complex leads to its degradation and subsequent NF-κB activation.
The IKK complex includes IKKa, IKKβ, and IKKK. TBK1 (also known as NAK or T2K) directly phosphorylates and activates IKKβ, mediating NF-κB activation in response to growth factors and PMA. TBK1 functions upstream of NIK and the IKK complex and plays a critical role in protecting embryonic liver from apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.