Thermo Fisher Scientific Collagen Type VI Polyclonal Antibody, Biotin

Thermo Fisher Scientific Collagen Type VI Polyclonal Antibody, Biotin

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Store vial at 4°C prior to restoration. Restore with 0.1 mL of deionized water (or equivalent).
• For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing.
• Centrifuge product if not completely clear after standing at room temperature.
• Product is stable for several weeks at 4°C as an undiluted liquid.
• Dilute only prior to immediate use.
• Expiration date is one year from date of restoration.

Typically negligible cross-reactivity against other types of collagens was detected by ELISA against purified standards.
Some class-specific anti-collagens may be specific for three-dimensional epitopes, resulting in diminished reactivity with denatured collagen or formalin-fixed, paraffin-embedded tissues.
This antibody reacts with most mammalian Type VI collagens and has negligible cross-reactivity with Type I, II, III, IV, and V collagens.
Non-specific cross-reaction with other human serum proteins or non-collagen extracellular matrix proteins is negligible.

Target Information

The extensive family of COL gene products (collagens) includes several chain types:

• Fibril-forming interstitial collagens (Types I, II, III, and V)
• Basement membrane collagens (Type IV)

Collagens are fibrous extracellular matrix proteins with high tensile strength and are major components of connective tissue such as tendons and cartilage.
All collagens contain a triple helix domain and often show lateral self-association to form complex connective tissues.
Several collagens also play roles in cell adhesion, essential for maintaining normal tissue architecture and function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.