Thermo Fisher Scientific P-Selectin (CD62P) Polyclonal Antibody
Thermo Fisher Scientific의 P-Selectin (CD62P) Polyclonal Antibody는 인간 시료에 반응하는 토끼 IgG 기반 항체로, Western blot 및 IHC(Paraffin)에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 세포 접착 및 염증 연구에 활용됩니다. 연구용 전용 제품입니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 0.5–1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence at the N-terminus of human CD62P (49–66aa KAYSWNISRKYCQNRYTD) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5 mg BSA |
| Contains | 0.05 mg sodium azide, 0.05 mg thimerosal |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2747086 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type I transmembrane glycoprotein involved in cell rolling regulation.
It is stored in Weibel-Palade bodies of endothelial cells and in α-granules of platelets. Upon activation by thrombin, histamine, complement 5a, Ca²⁺ ionophores, or ADP, P-selectin translocates to the cell surface.
It mediates interactions between activated endothelial cells or platelets and leukocytes, functioning as a calcium-dependent receptor binding sialylated Lewis carbohydrate antigens on neutrophils and monocytes.
P-selectin is constitutively expressed during inflammation and contributes to atherogenesis, thrombosis, and tissue destruction. Clinically, it is used to distinguish heparin-induced thrombocytopenia with and without thrombosis.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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