Thermo Fisher Scientific P-Selectin (CD62P) Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type I transmembrane glycoprotein involved in cell rolling regulation.
It is stored in Weibel-Palade bodies of endothelial cells and in α-granules of platelets. Upon activation by thrombin, histamine, complement 5a, Ca²⁺ ionophores, or ADP, P-selectin translocates to the cell surface.
It mediates interactions between activated endothelial cells or platelets and leukocytes, functioning as a calcium-dependent receptor binding sialylated Lewis carbohydrate antigens on neutrophils and monocytes.
P-selectin is constitutively expressed during inflammation and contributes to atherogenesis, thrombosis, and tissue destruction. Clinically, it is used to distinguish heparin-induced thrombocytopenia with and without thrombosis.

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.