Thermo Fisher Scientific CXCR3 Polyclonal Antibody, FITC
CXCR3 단백질을 인식하는 FITC 결합 토끼 폴리클로날 항체로, WB, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. 마우스 및 랫트 반응성, 498/517 nm 형광 특성, 친화 크로마토그래피 정제 및 안정한 보관 조건을 제공합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| Immunocytochemistry (ICC/IF) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
| Immunomicroscopy (IM) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 20–70 on rat CXCR3 protein |
| Conjugate | FITC (Fluorescein) |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA and 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes a G protein-coupled receptor with selectivity for three chemokines: IP10 (interferon-γ-inducible 10 kDa protein), Mig (monokine induced by interferon-γ), and I-TAC (interferon-inducible T cell α-chemoattractant). These chemokines belong to the CXC subfamily, characterized by a single amino acid residue separating the first two of four conserved cysteine residues.
Binding of chemokines to CXCR3 induces cellular responses such as leukocyte trafficking, integrin activation, cytoskeletal rearrangement, and chemotactic migration. Pertussis toxin inhibition indicates coupling with Gi-type G proteins. The receptor undergoes phosphorylation-dependent internalization upon activation, leading to rapid but transient responses, followed by receptor recycling.
CXCR3 is highly expressed in effector/memory T cells and inflamed tissues, playing a key role in immune cell recruitment during inflammation. Consequently, it is a potential target for small-molecule antagonists in inflammatory disease treatment. Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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