Thermo Fisher Scientific Phospho-TAK1 (Thr187) Polyclonal Antibody
TAK1 단백질의 Thr187 인산화 상태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC 등 다양한 응용에 적합. Human, Mouse, Rat 시료 반응. 고순도 정제 및 -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:500 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MAP3K7 (Accession O43318), corresponding to amino acid residues around phosphorylated Thr187. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818273 |
Product Specific Information
Antibody detects endogenous levels of TAK1 only when phosphorylated at Threonine 187.
Target Information
TAK1 (also known as MAP3K7) is a serine/threonine kinase involved in multiple signaling pathways. It was initially identified as a TGF-beta-activated kinase that interacts with TGF-beta receptor and TRAF6 to modulate activation of JNK and p38. TAK1 also participates in signaling through Wnt, BMP, activin, thyroid hormone, osmotic stress, endothelin, and ephrine pathways.
It regulates wound healing by promoting von Hippel-Lindau tumor suppressor expression and repressing PDGF-B and integrins β1/β5. TAK1 is essential for IKK activation in IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I signaling. Activation involves TAB2/3 binding and ubiquitination, followed by TAK1 autophosphorylation at Thr178, Thr184, Thr187, and Ser192, leading to IKK-β phosphorylation. TAK1 also represses human telomerase reverse transcriptase, indicating a role in cell lifespan regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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