Thermo Fisher Scientific ZBED1 Monoclonal Antibody (OTI2A7), TrueMAB
ZBED1 단백질을 타깃으로 하는 Thermo Fisher Scientific의 단클론 항체. Western blot, IHC, ICC/IF에 적합하며, 인간 시료에 반응. 동결건조 형태로 제공되며, 재구성 후 약 1 mg/mL 농도로 사용 가능. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2A7 |
| Immunogen | Full length human recombinant protein of human ZBED1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, it is recommended to perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
ZBED1 (also known as DREF) is the human homolog of the Drosophila DREF protein, a transcriptional regulatory factor required for expression of genes involved in DNA replication and cell proliferation.
RNA interference targeting ZBED1 RNA inhibits S phase entry and reduces histone H1 mRNA levels in HeLa cells, indicating a role in human cell proliferation.
ZBED1 binds to promoter regions of at least 22 ribosomal protein genes, and ZBED1 knockdown decreases their expression.
Immunoprecipitation studies show that ZBED1 self-associates via a carboxyl-terminal hATC domain, which is necessary for nuclear localization and DNA binding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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