Thermo Fisher Scientific ZBED1 Monoclonal Antibody (OTI2A7), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, it is recommended to perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

ZBED1 (also known as DREF) is the human homolog of the Drosophila DREF protein, a transcriptional regulatory factor required for expression of genes involved in DNA replication and cell proliferation.
RNA interference targeting ZBED1 RNA inhibits S phase entry and reduces histone H1 mRNA levels in HeLa cells, indicating a role in human cell proliferation.
ZBED1 binds to promoter regions of at least 22 ribosomal protein genes, and ZBED1 knockdown decreases their expression.
Immunoprecipitation studies show that ZBED1 self-associates via a carboxyl-terminal hATC domain, which is necessary for nuclear localization and DNA binding.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.