Thermo Fisher Scientific Sclerostin Monoclonal Antibody (5D8D2D4)
인간 SOST/Sclerostin 단백질을 인식하는 단클론 항체로, ELISA에 적합합니다. 방부제가 포함되지 않아 오염 방지를 위해 sodium azide 첨가를 권장합니다. 단백질 A로 정제된 액상 형태이며, 단기 4°C, 장기 -20°C 보관이 가능합니다.
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Applications
ELISA (ELISA)
- Tested Dilution: 1:1,000–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5D8D2D4 |
| Immunogen | Recombinant Human SOST protein (Gln24–Tyr213) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.18 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2785636 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human SOST/Sclerostin.
Target Information
Sclerostin, a glycoprotein predominantly secreted by osteocytes, belongs to the Cerberus/DAN family of BMP antagonists and functions as an endogenous regulator of the canonical Wnt signaling pathway and bone homeostasis.
Although mainly expressed by osteocytes, it is also found in bone, bone marrow, cartilage, kidney, and liver, and is produced by hypertrophic chondrocytes and cementocytes.
Sclerostin regulates the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LRP5 and LRP6, and interacts with LRP4 to facilitate inhibition of Wnt signaling.
It can promote osteoclast activity by increasing osteocyte expression of RANKL.
Mutations leading to decreased sclerostin levels cause bone dysplasia disorders such as sclerosteosis and van Buchem disease (VBD), characterized by progressive bone overgrowth and hypermineralization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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