Thermo Fisher Scientific Sclerostin Monoclonal Antibody (5D8D2D4)

Applications

ELISA (ELISA)

• Tested Dilution: 1:1,000–1:2,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human SOST/Sclerostin.

Target Information

Sclerostin, a glycoprotein predominantly secreted by osteocytes, belongs to the Cerberus/DAN family of BMP antagonists and functions as an endogenous regulator of the canonical Wnt signaling pathway and bone homeostasis.
Although mainly expressed by osteocytes, it is also found in bone, bone marrow, cartilage, kidney, and liver, and is produced by hypertrophic chondrocytes and cementocytes.
Sclerostin regulates the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LRP5 and LRP6, and interacts with LRP4 to facilitate inhibition of Wnt signaling.
It can promote osteoclast activity by increasing osteocyte expression of RANKL.
Mutations leading to decreased sclerostin levels cause bone dysplasia disorders such as sclerosteosis and van Buchem disease (VBD), characterized by progressive bone overgrowth and hypermineralization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.