Thermo Fisher Scientific BAP1 Polyclonal Antibody
BAP1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF, Flow cytometry에 적합하며 Human, Mouse, Rat 반응성. Protein A 정제, 0.5 mg/mL 농도, 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:25 | - |
| Flow Cytometry (Flow) | 1:25 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 36–66 amino acids of human BAP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2290058 |
Product Specific Information
This antibody is predicted to react with bovine, rat, and zebrafish based on sequence homology.
Target Information
BRCA1-associated protein-1 (BAP1) interacts with the RING finger domain of BRCA1. The N-terminal 240 amino acids of the 729-amino acid human protein show homology to ubiquitin C-terminal hydrolases (UCHs), thiol proteases that catalyze proteolytic processing of ubiquitin.
BAP1 contains an acidic region, a highly charged C-terminal region, and two nuclear localization signals. It associates with BRCA1 in vivo and enhances BRCA1-mediated inhibition of breast cancer cell growth.
Northern blot analysis shows BAP1 expression as a 4-kb mRNA in all human tissues, with a 4.8-kb transcript expressed exclusively in testis. BAP1 and BRCA1 are coexpressed during murine breast development and remodeling.
The BAP1 gene is mapped to 3p21.3, a region often deleted in breast and lung carcinomas, suggesting it may function as a tumor suppressor gene in the BRCA1 growth control pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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