Thermo Fisher Scientific Phospho-IRAK1 (Ser376) Polyclonal Antibody
인간 IRAK1의 Ser376 인산화 부위를 인식하는 폴리클로날 항체로, IHC(P) 실험에 적합합니다. Rabbit IgG로 제작되었으며, 친화 크로마토그래피로 정제되었습니다. 1 mg/mL 농도의 액상 형태로 제공되며, -20°C에서 보관합니다.
- 카탈로그번호
- PA537611
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:100
- Suggested positive control: Human brain tissue
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of Serine 376 (Q-S-S(p)-M-V) derived from Human IRAK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | Dulbecco’s PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2554219 |
Target Information
IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. Upon TLR activation, IRAK1 is rapidly recruited by MYD88 to the receptor-signaling complex. IRAK1 is phosphorylated by IRAK4, then undergoes autophosphorylation and activation. It can phosphorylate TIRAP to promote ubiquitination and degradation, and also phosphorylates IRF7, leading to its activation and translocation to the nucleus, thereby inducing type I interferon gene transcription and antiviral responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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