Thermo Fisher Scientific Phospho-ITGB1 (Tyr795) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000
• Suggested Positive Control: COS7 cells

Product Specifications

Product Specific Information

A suggested positive control for Western blot is COS7 cells.

Target Information

ITGB1 (Integrin Subunit Beta 1, CD29) is a 110 kDa cell surface glycoprotein expressed by various cell types including all leukocytes.

• Forms non-covalent heterodimers with at least six alpha chains (α1–α6), determining binding properties of β1 (VLA) integrins.
• Functions as a cell adhesion molecule on platelets and as a component of protein complexes binding to extracellular matrix proteins.
• Decreased ITGB1 expression correlates with multidrug resistance in tumor cells.
• Upregulated during leukocyte migration and involved in immune cell trafficking and inflammatory regulation.
• Plays a role in tissue damage and inflammatory bowel disease.
• Through ITGB1-dependent mechanisms, fibronectin and type I collagen enhance cytokine secretion in human airway smooth muscle cells in response to IL-1β.
• Two major forms exist: β1A (present in all tissues except cardiac/skeletal muscle) and β1D (expressed in cardiac/skeletal muscle).

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.