Thermo Fisher Scientific CD275 (B7-H2) Recombinant Rat Monoclonal Antibody (HK5.3)
Thermo Fisher Scientific의 CD275 (B7-H2) 재조합 Rat Monoclonal Antibody (HK5.3)는 마우스 ICOSL에 특이적으로 결합하며 ICOS 결합을 경쟁적으로 억제합니다. Flow Cytometry 및 Inhibition Assay에 사용 가능하며, HEK293 세포에서 발현된 IgG2a 형 Rat 항체입니다. Protein A로 정제된 액상 형태로 제공됩니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
Inhibition Assays (IA)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | HK5.3 |
| Immunogen | This antibody was raised by immunizing SD rat with mouse B7h-transfected L cells and fusing immune splenocytes with P3U1 myeloma cells and screened for binding to mouse B7h-transfected NRK cells. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_3074542 |
Product Specific Information
Specificity: This antibody specifically binds to mouse ICOSL and competes with binding of ICOS.
Target Information
Inducible co-stimulator ligand (ICOSL) is a specific ligand on antigen-presenting cells and peripheral tissue cells that binds to the inducible co-stimulator receptor (ICOS). ICOS belongs to the CD28/CD152 receptor family that regulates T-cell activation and function. ICOSL is expressed on monocytes, dendritic cells, and B cells and can be induced by inflammatory stimuli in peripheral tissue. Binding to ICOSL delivers a co-stimulatory signal for T cell proliferation and cytokine secretion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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