Thermo Fisher Scientific SP1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.3–1 µg/mL

Product Specifications

Product Specific Information

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:8,000.

Target Information

SP1 is a transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. It binds with high affinity to GC-rich motifs and regulates expression of numerous genes involved in processes such as cell growth, apoptosis, differentiation, and immune responses. SP1 activity is highly regulated by post-translational modifications including phosphorylation, sumoylation, proteolytic cleavage, glycosylation, and acetylation. It also binds the PDGFR-alpha G-box promoter and may modulate cellular responses to DNA damage. SP1 is implicated in chromatin remodeling and plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter, as well as in the regulation of FE65 gene expression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.