Thermo Fisher Scientific ITIH4 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.03 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

4-6 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide with sequence ERLCVDPRHRQGPVN. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ITIH4,uniProtId:Q14624-1,ncbiNodeId:9606,antigenRange:744-758,antigenLength:930,antigenImageFileName:PA5-142437_ITIH4_Q14624-1_Goat.svg,antigenImageFileNamePDP:PA5-142437_ITIH4_Q14624-1_Goat_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Ammonium sulfate precipitation

Storage buffer

TBS, pH 7.3, with 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2933085

Product Specific Information

Additional Information: The immunizing peptide represents a region of the 35kDa chain. This chain is glycosylated giving rise to an apparent higher molecular weight.

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:16,000.

Target Information

The inter-alpha-trypsin inhibitor (ITI, I-alpha-I) family is a classic example of protein-glycosaminoglycoprotein (PGP) complexes. They occur constitutively in plasma at relatively high concentrations and results from alternating combinations of three kinds of heavy chains with a common light chain called the bikunin proteoglycan. Bikunin has two proteinase inhibotor domains and belongs to the Kunitz-type protease inhibitor family; it displays an inhibitory activity against trypsin, leukocyte elastase and plasmin. The heavy chains do not have any protease inhibitory properties but have the capacity to interact in vitro and in vivo with hyaluronic acid and this binding promotes the stability of the extra-cellular matrix. The ITI protein family is suspected of playing a key role in the extra-cellular matrix biology.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.