Thermo Fisher Scientific ITIH4 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• The immunizing peptide represents a region of the 35 kDa chain, which is glycosylated, resulting in an apparent higher molecular weight.
• This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:16,000.

Target Information

The inter-alpha-trypsin inhibitor (ITI, I-alpha-I) family is a classic example of protein-glycosaminoglycoprotein (PGP) complexes.
They occur constitutively in plasma at relatively high concentrations and result from alternating combinations of three kinds of heavy chains with a common light chain called the bikunin proteoglycan.

Bikunin has two proteinase inhibitor domains and belongs to the Kunitz-type protease inhibitor family; it displays inhibitory activity against trypsin, leukocyte elastase, and plasmin.
The heavy chains do not have protease inhibitory properties but can interact with hyaluronic acid, promoting the stability of the extracellular matrix.
The ITI protein family is suspected of playing a key role in extracellular matrix biology.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.