Thermo Fisher Scientific Doublecortin Polyclonal Antibody
Doublecortin 단백질을 인식하는 Rabbit Polyclonal 항체로, 인간, 생쥐, 랫드에 반응합니다. WB, IHC, ICC 등 다양한 응용에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 신경세포 이동 관련 연구에 적합한 고품질 연구용 항체입니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | - | 3 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | 1 publication |
| Immunocytochemistry (ICC/IF) | 1:200–1:800 | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to human doublecortin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 130 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10977233 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
In the developing cortex, cortical neurons must migrate over long distances to reach their final differentiation sites. DCX (Doublecortin) is a cytoplasmic protein that directs neuronal migration by regulating microtubule organization and stability. It contains two doublecortin domains that bind microtubules and interacts with LIS1, a regulatory subunit of platelet-activating factor acetylhydrolase. This interaction is crucial for proper microtubule function during cortical development. Mutations in the DCX gene cause X-linked lissencephaly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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