Thermo Fisher Scientific GSTM1 Monoclonal Antibody (1H4F2)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

MA5-17085 targets GSTM1 in FACS, IHC, indirect ELISA, and WB applications and shows reactivity with Human and Rat samples.
The immunogen is a purified recombinant fragment of human GSTM1 expressed in E. coli.
MA5-17085 detects GSTM1, which has a predicted molecular weight of approximately 26 kDa.

Target Information

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families.
Eight distinct classes of soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta, and zeta.
This gene encodes a glutathione S-transferase belonging to the mu class, functioning in detoxification of electrophilic compounds including carcinogens, therapeutic drugs, environmental toxins, and oxidative stress products by conjugation with glutathione.
The mu class genes are located on chromosome 1p13.3 and are highly polymorphic, affecting susceptibility to carcinogens and drug responses.
Null mutations of this gene have been linked with increased risk of various cancers due to reduced detoxification capacity.
Multiple protein isoforms are encoded by transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.