Thermo Fisher Scientific HP1 beta Recombinant Human Monoclonal Antibody (RAB-C145)
CBX1 단백질을 인식하는 인간 재조합 단일클론 항체로, ICC/IF, ELISA, ChIP 등 다양한 응용에 적합합니다. HEK293에서 발현되며, 1 mg/mL 농도의 액상 형태로 제공됩니다. 금속 킬레이트 크로마토그래피로 정제되어 높은 순도를 보장합니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: Assay-dependent
ELISA
- Tested Dilution: Assay-dependent
ChIP assay (ChIP)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Human / F(ab), kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | RAB-C145 |
| Immunogen | Recombinant antibody (rAb) phage display recognizing CBX1 protein under non-denaturing conditions |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Metal-chelate chromatography |
| Storage buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
Product Specific Information
This antibody recognizes CBX1 (Chromobox protein homolog 1). It binds to a folded domain (amino acids 20–73).
CBX1 is a component of heterochromatin and recognizes histone H3 tails methylated at Lys-9, leading to epigenetic repression.
Target Information
This gene encodes a highly conserved nonhistone protein belonging to the heterochromatin protein family.
It is enriched in heterochromatin and associated with centromeres.
The protein contains:
- An N-terminal chromodomain that binds histone proteins via methylated lysine residues
- A C-terminal chromo shadow-domain responsible for homodimerization and interaction with chromatin-associated nonhistone proteins
CBX1 plays an important role in epigenetic control of chromatin structure and gene expression.
Several related pseudogenes exist on chromosomes 1, 3, and X.
Multiple alternatively spliced variants encoding the same protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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