Thermo Fisher Scientific SENP8 Polyclonal Antibody
SENP8 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 IHC(P)에서 사용 가능. Human, Mouse, Rat에 반응하며, 항원 친화 크로마토그래피로 정제. NEDD8 경로 조절 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from internal region of human SENP8 (aa 180–209, UniProt ID: Q96LD8-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635207 |
Product Specific Information
This antibody detects endogenous levels of total SENP8 protein.
Target Information
SENP8 (Cysteine protease FKSG8; DEN1; FKSG8; HsT17512; NEDP1; PRSC2; SUMO/sentrin specific protease family member 8) is a novel cysteine protease belonging to the ULP family of deubiquitinases. Members of this family have a C-terminal catalytic domain and N-terminal extensions that determine substrate specificity.
SENP8, a 24 kDa protein, plays a major role in regulating the NEDD8 pathway by processing preNEDD8 to its mature form and deconjugating NEDD8 from substrates such as Cullins and p53. It helps prevent accumulation of hyper-neddylated cullins and maintains mono-neddylated cullin levels, thereby enhancing ubiquitination efficiency by SCF ubiquitin ligases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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