Thermo Fisher Scientific TGF beta-3 Polyclonal Antibody
TGF beta-3 단백질의 내인성 수준을 검출하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot과 IHC(Paraffin)에 적합하며, Human, Mouse, Rat 반응성. 고순도 항원 친화 크로마토그래피 정제, 안정적인 액상 형태로 연구용에 적합.
- 카탈로그번호
- PA549752
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human TGF beta-3 (UniProt ID: P10600-1, antigen range: 282–309, antigen length: 412) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635205 |
Product Specific Information
This antibody detects endogenous levels of total TGF beta-3 protein.
Target Information
Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer.
TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity. Members of this family can be expressed by most cell types and exert pleiotropic effects, including:
- Suppression of B- and T-cell effector activity
- Mediation of tissue healing
- Suppression of tumor proliferation
- Promotion of CD4+CD25+ T-cell expansion, indicating a role in protection against autoimmunity
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-49752_TGF_beta-3_P10600-1_Rabbit.svg, PA5-49752_TGF_beta-3_P10600-1_Rabbit_PDP.jpeg)
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