Thermo Fisher Scientific TGF beta-3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:100

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total TGF beta-3 protein.

Target Information

Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer.

TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity. Members of this family can be expressed by most cell types and exert pleiotropic effects, including:

• Suppression of B- and T-cell effector activity
• Mediation of tissue healing
• Suppression of tumor proliferation
• Promotion of CD4+CD25+ T-cell expansion, indicating a role in protection against autoimmunity

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일명: PA5-49752_TGF_beta-3_P10600-1_Rabbit.svg, PA5-49752_TGF_beta-3_P10600-1_Rabbit_PDP.jpeg)