Thermo Fisher Scientific ATM Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:5,000

Immunoprecipitation (IP)

• Tested Dilution: 2–5 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt.

Target Information

Ataxia-telangiectasia Mutated (ATM) is a protein that belongs to the PI3/PI4 kinase family.
Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and increased risk of lymphoid cancer.
The ATM gene encodes a protein that phosphorylates other proteins, acting as a key regulator in the DNA damage response.
ATM targets include P53, Mdm2, BRCA1, and SMC1, and plays a critical role in repairing double-stranded DNA breaks caused by ionizing radiation.
The C-terminal region of ATM shares homology with the catalytic domains of PI3 kinases.
ATM becomes autophosphorylated and activated upon exposure to ionizing radiation, initiating kinase cascades that regulate cell cycle, apoptosis, and DNA damage repair.
ATM is also linked to apoptosis through interactions with Nbs1 and Chk2 in the E2F1 pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.