Thermo Fisher Scientific ATM Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:5,000

Immunoprecipitation (IP)

• Tested Dilution: 2–5 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt.

Target Information

Ataxia-telangiectasia Mutated (ATM) is a protein belonging to the PI3/PI4 kinase family.
Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and increased risk of lymphoid cancer.
The ATM gene encodes a protein that phosphorylates proteins instead of lipids and regulates cell cycle through downstream targets such as P53, Mdm2, BRCA1, and SMC1.
ATM is crucial for repairing double-stranded DNA breaks caused by ionizing radiation and other mutagens.
Its C-terminal region shows homology to catalytic domains of PI3 kinases.
ATM becomes autophosphorylated and upregulated upon exposure to ionizing radiation, activating kinase cascades that control cell cycle, apoptosis, and DNA damage repair.
ATM also interacts with Nbs1 and Chk2 in the E2F1 pathway related to apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.