Thermo Fisher Scientific ATM Polyclonal Antibody
ATM 단백질을 인식하는 염소 유래 폴리클로날 항체로, Western blot 및 Immunoprecipitation에 적합합니다. 인간 ATM 단백질의 1750–1800번 잔기 영역을 면역원으로 사용하였으며, 1 mg/mL 농도의 액상 형태로 제공됩니다. DNA 손상 및 세포주기 조절 연구에 활용됩니다.
- 카탈로그번호
- A300135Ax (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific ATM Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:5,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 1750 and 1800 of human Ataxia Telangiectasia Mutated |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
Ataxia-telangiectasia Mutated (ATM) is a protein belonging to the PI3/PI4 kinase family.
Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and increased risk of lymphoid cancer.
The ATM gene encodes a protein that phosphorylates proteins instead of lipids and regulates cell cycle through downstream targets such as P53, Mdm2, BRCA1, and SMC1.
ATM is crucial for repairing double-stranded DNA breaks caused by ionizing radiation and other mutagens.
Its C-terminal region shows homology to catalytic domains of PI3 kinases.
ATM becomes autophosphorylated and upregulated upon exposure to ionizing radiation, activating kinase cascades that control cell cycle, apoptosis, and DNA damage repair.
ATM also interacts with Nbs1 and Chk2 in the E2F1 pathway related to apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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