Thermo Fisher Scientific TNIK Polyclonal Antibody
TNIK 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC 등 다양한 응용 가능. 고순도(Ammonium sulfate precipitation)로 정제된 액상 항체. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | - |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 1–30 amino acids from the N-terminal region of human TNIK |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2207637 |
Target Information
TNIK (TRAF2 and NCK interacting kinase) is characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function. TNIK is mainly expressed in brain, heart, and spleen and acts as a specific effector of RAP2, which regulates the actin cytoskeleton. It is autophosphorylated depending on lys54 in the ATP-binding pocket of its kinase domain and plays a key role in cytoskeleton regulation. TNIK also phosphorylates gelsolin, an actin-severing protein, suggesting its involvement in cytoskeletal organization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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