Thermo Fisher Scientific APP Monoclonal Antibody (OTI7B8), TrueMAB

Thermo Fisher Scientific APP Monoclonal Antibody (OTI7B8), TrueMAB

Applications and Tested Dilution

Product Specifications

Additional Formats

• Biotin Conjugate
• Request Custom Conjugation

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Amyloid Precursor Protein (APP) functions as a cell surface kinesin I membrane receptor, mediating axonal transport of beta-secretase and presenilin 1.
APP is involved in neurite growth, neuronal adhesion, and axonogenesis. It is a 100–140 kDa transmembrane glycoprotein with multiple isoforms generated by alternative splicing.
Proteolytic cleavage of APP by beta- and gamma-secretases produces beta amyloid, the main component of senile plaques—key histopathologic features of Alzheimer’s disease.
Abnormal APP regulation and processing are associated with Down’s syndrome, early-onset familial Alzheimer’s disease, and cerebral hemorrhage.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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