Thermo Fisher Scientific APP Monoclonal Antibody (OTI7B8), TrueMAB
인간 APP 단백질을 표적으로 하는 Mouse IgG2a 단일클론 항체로, WB 및 IHC(P)에서 검증됨. 동결건조 형태로 제공되며, 트레할로스가 포함된 PBS buffer에 보관. 알츠하이머병 및 신경세포 연구에 적합한 연구용 항체.
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Thermo Fisher Scientific APP Monoclonal Antibody (OTI7B8), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7B8 |
| Immunogen | Full-length human recombinant APP protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS (pH 7.3) with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Amyloid Precursor Protein (APP) functions as a cell surface kinesin I membrane receptor, mediating axonal transport of beta-secretase and presenilin 1.
APP is involved in neurite growth, neuronal adhesion, and axonogenesis. It is a 100–140 kDa transmembrane glycoprotein with multiple isoforms generated by alternative splicing.
Proteolytic cleavage of APP by beta- and gamma-secretases produces beta amyloid, the main component of senile plaques—key histopathologic features of Alzheimer’s disease.
Abnormal APP regulation and processing are associated with Down’s syndrome, early-onset familial Alzheimer’s disease, and cerebral hemorrhage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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