Thermo Fisher Scientific DBI Polyclonal Antibody
인간 DBI 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, ELISA, IP 등 다양한 응용에 적합. 고순도 Affinity Chromatography 정제, PBS/glycerol 버퍼에 보존. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1 µg/mL
Immunoprecipitation (IP)
- Tested Dilution: 0.5 µg–4 µg antibody for 200 µg–400 µg extracts
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–104 of human DBI (NP_001171513.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.27 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806493 |
Product Specific Information
- Immunogen sequence: MWGDLWLLPP ASANPGTGTE AEFEKAAEEV RHLKTKPSDE EMLFIYGHYK QATVGDINTE RPGMLDFTGK AKWDAWNELK GTSKEDAMKA YINKVEELKK KYGI
- Positive Samples: HT-29, THP-1, MCF7, NCI-H460, A673, U-937, U-251MG
- Cellular Location: Endoplasmic reticulum, Golgi apparatus
Target Information
This gene encodes diazepam binding inhibitor, a protein regulated by hormones and involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors in brain synapses.
The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that form the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters.
Diazepam binding inhibitor mediates feedback regulation of pancreatic secretion and postprandial release of cholecystokinin, and acts as a mediator in corticotropin-dependent adrenal steroidogenesis.
Three pseudogenes are located on chromosomes 6, 8, and 16. Multiple transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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