Thermo Fisher Scientific beta-2 Adrenergic Receptor Recombinant Rabbit Monoclonal Antibody (JM102-06)
Western blot 및 IHC(P)에서 검증된 beta-2 Adrenergic Receptor 특이적 항체. 인간, 생쥐, 랫드, 제브라피시에 반응. 재조합 토끼 단클론 항체로 높은 특이성과 재현성 제공. 단백질 A 정제, 1 mg/mL 농도, 4°C 또는 -20°C 보관.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:5,000–1:20,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:5,000 | — |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat, Zebrafish |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JM102-06 |
| Immunogen | Synthetic peptide within Human ADRB2 aa 369–400 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809847 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the larger rabbit immune repertoire
Target Information
Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor (GPCR) superfamily that bind endogenous catecholamines epinephrine and norepinephrine.
Nine receptor subtypes have been identified:
- Alpha-1 AR: 1A/D, 1B, 1C
- Alpha-2 AR: 2A, 2B, 2C
- Beta AR: 1, 2, 3
ARs are involved in the onset or maintenance of various disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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