Thermo Fisher Scientific BAG4 Polyclonal Antibody
Human BAG4 단백질에 대한 Rabbit Polyclonal Antibody로, Western blot 및 Flow cytometry에 사용 가능. 단백질 G로 정제된 액상 형태이며, PBS와 젤라틴 버퍼에 보관. HeLa 세포 추출물로 검증된 양성 대조군 추천.
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Applications
Western Blot (WB)
- Tested Dilution: 2–4 µg/mL
Flow Cytometry (Flow)
- Tested Dilution: 1:10–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 443–457 of human SODD |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 0.2% gelatin |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2062634 |
Product Specific Information
Suggested positive control: HeLa whole cell extract, HeLa cell lysate.
Target Information
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that interacts with various apoptosis and growth-related proteins, including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors, and heat shock protein 70 kDa family.
This protein contains a BAG domain near the C-terminus, which can bind and inhibit the chaperone activity of Hsc70/Hsp70. It associates with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), thereby negatively regulating downstream cell death signaling.
Its regulatory role in cell death was demonstrated in epithelial cells undergoing apoptosis upon loss of integrin-mediated matrix contacts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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