Thermo Fisher Scientific DR6 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human DR6 (TNFRSF21) residues 371–655. Validated for Western blot at 2–4 µg/mL. Useful for apoptosis and TNF receptor pathway studies. Supplied as liquid, 0.5 mg/mL, stored at 4°C or -20°C.
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Thermo Fisher Scientific DR6 Polyclonal Antibody
Applications
- Western Blot (WB): 2–4 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 371–655 of human DR6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2206798 |
Product Specific Information
Suggested positive control: antigen standard for TNFRSF21 (transient overexpression lysate), Daudi, HeLa, or Jurkat.
Target Information
DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kappa-B and JNK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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