Thermo Fisher Scientific Phospho-TRKB (Tyr817) Polyclonal Antibody
Phospho-TRKB (Tyr817) 폴리클로날 항체로 인간, 생쥐, 랫트 반응성. Western blot, IHC, ICC/IF에 사용 가능. TrkB의 Tyr817 인산화 상태를 특이적으로 검출. 신경계 발달 및 BDNF 관련 연구에 적합.
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Thermo Fisher Scientific Phospho-TRKB (Tyr817) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human NTRK2 (Accession Q16620), corresponding to amino acid residues around phosphorylated Tyr817 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817499 |
Product Specific Information
This antibody detects endogenous levels of TrkB only when phosphorylated at Tyr817.
Target Information
NTRK2 (TRKB) is part of the neurotrophic factor receptor family essential for the development and maintenance of the mammalian nervous system. It acts as the receptor for brain-derived neurotrophic factor (BDNF), regulating synaptic functions and long-term potentiation. TrkB is a membrane-bound tyrosine kinase receptor involved in MAPK pathway activation and cell differentiation. Mutations in TrkB have been linked to obesity and mood disorders. Various splice variants encoding different isoforms exist.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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