Thermo Fisher Scientific NUP98 Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1:1,000

Product Specifications

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins.
The 98 kDa nucleoporin is generated through synthesis and proteolytic cleavage of a 186 kDa precursor protein, resulting in the 98 kDa and 96 kDa nucleoporins localized to the nucleoplasmic side of the NPC.
Rat studies show that the 98 kDa nucleoporin functions as a docking site nucleoporin for transport substrates.
The human NUP98 gene can fuse with other genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL).
This gene is located in the imprinted gene domain of 11p15.5, a tumor-suppressor region associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and various cancers.
Alternative splicing results in several transcript variants, not all of which have been fully described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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