Thermo Fisher Scientific PAR4 Polyclonal Antibody
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PAR4 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 등 다양한 종에 반응합니다. Western blot, ICC/IF, Flow cytometry, IP에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 암세포에서의 세포사멸 연구에 활용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
| Flow Cytometry (Flow) | 1:50 | 1 publication |
| Immunoprecipitation (IP) | 1:100 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues surrounding Arg220 of human PAR-4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 65 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11009182 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms.
- Intracellular mechanism: Inhibition of pro-survival pathways and activation of Fas-mediated apoptosis.
- Extracellular mechanism: Binding of secreted protein form to GRP78 on the cell surface, leading to activation of the extrinsic apoptotic pathway.
This gene is located on the unstable human chromosomal region 12q21 and is often deleted or mutated in different tumors. The encoded protein also contributes to the progression of age-related diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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