Thermo Fisher Scientific PHLPP1 Polyclonal Antibody
PHLPP1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, WB, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 액상 형태로 -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1160–1428 of human PHLPP1 (NP_919431.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.94 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914806 |
Product Specific Information
Positive test controls include: HeLa, SH-SY5Y, Mouse testis, Mouse brain, Rat testis, Rat brain.
The target is usually found in the following locations: Cell membrane, Cytoplasm, Membrane, Nucleus, Peripheral membrane protein.
Immunogen sequence:
DQPSTGDASG APAVWSHGYT EASGVKNKLC VAALSVNNFC DNREALYGVF DGDRNVEVPY LLQCTMSDIL AEELQKTKNE EEYMVNTFIV MQRKLGTAGQ KLGGAAVLCH IKHDPVDPGG SFTLTSANVG KCQTVLCRNG KPLPLSRSYI MSCEEELKRI KQHKAIITED GKVNGVTEST RILGYTFLHP SVVPRPHVQS VLLTPQDEFF ILGSKGLWDS LSVEEAVEAV RNVPDALAAA KKLCTLAQSY GCHDSISAVV VQLSVTEDS
Target Information
PHLPP1 is a member of the serine/threonine phosphatase family, which are important regulators of Akt serine-threonine kinases (AKT1, AKT2, AKT3) and conventional/novel protein kinase C (PKC) isoforms.
PHLPP1 and PHLPP2 have similar domain structures and dephosphorylate distinct Akt isoforms at Serine473.
PHLPP2 dephosphorylates AKT1 and AKT3, whereas PHLPP1 is specific for AKT2 and AKT3.
PHLPP1 promotes apoptosis and may act as a tumor suppressor. Increased expression of PHLPP1 may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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