Thermo Fisher Scientific PKA alpha Monoclonal Antibody (7H3A4)
PKA alpha 단백질을 표적하는 Thermo Fisher Scientific의 Mouse IgG1 단일클론 항체. Western blot과 ELISA에 적합하며, 정제된 PRKACA 단백질 조각을 면역원으로 사용. 1 mg/mL 농도의 액상 형태로 제공되며, 단백질 G로 정제됨. 연구용으로만 사용 가능.
- 카탈로그번호
- MA531865
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7H3A4 |
| Immunogen | Purified recombinant fragment of human PRKACA (AA: 1–120) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787488 |
Product Specific Information
MA5-31865 has been tested in indirect ELISA.
Target Information
The PKC family of serine/threonine kinases, including PRKCA (PKC alpha), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca²⁺- and phospholipid-dependent.
Protein kinase C (PKC) can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters.
Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase plays roles in cell adhesion, transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest it may regulate cardiac contractility and Ca²⁺ handling in myocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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