Thermo Fisher Scientific B7-H4 Monoclonal Antibody (H74), eBioscience
Human B7-H4 단백질을 인식하는 H74 클론의 마우스 모노클로날 항체로, Flow Cytometry 등 다양한 면역분석에 사용 가능. 0.5 mg/mL 농도의 액상 형태이며, PBS buffer에 sodium azide 포함. 높은 순도(>90%)와 낮은 aggregation(<10%)으로 안정적 성능 제공.
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Thermo Fisher Scientific B7-H4 Monoclonal Antibody (H74), eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 2 publications |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Flow Cytometry (Flow) | 0.25 µg/test | - |
| ELISA | - | View 2 publications |
| Neutralization | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | H74 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_467739 |
Additional Formats Available:
- APC
- Biotin
- Functional Grade
- PE
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Custom conjugation available upon request
Product Specific Information
The H74 monoclonal antibody was generated and reacts with human B7-S1, also known as B7-H4 and B7x. Cross-reactivity to other proteins has not been determined. B7S1 is a newly discovered member of the B7 family and may influence T-cell costimulation depending on B-cell activation status. Although BTLA is reported as a counter receptor, further studies are needed to confirm the B7-H4 ligand.
H74 stains human B7-H4 transfected cells but not peripheral blood cells. The exact expression pattern of B7-H4 remains incompletely characterized.
Applications Reported: Flow cytometric analysis.
Applications Tested: Flow cytometric analysis of transient hB7-H4 transfected cells. Recommended ≤0.25 µg per test (100 µL final volume). Optimal titration is advised for best assay performance.
Purity: >90% (SDS-PAGE)
Aggregation: <10% (HPLC)
Filtration: 0.2 µm post-manufacturing filtered
Target Information
B7-H4 (also known as B7x, VTCN1) is a costimulatory protein functioning as a negative regulator of T-cell mediated immunity. Although its receptor is unknown, B7-H4 inhibits T-cell proliferation, cell cycle progression, and IL-2 production. It is expressed on activated T-cells, B-cells, monocytes, and dendritic cells, and aberrant expression is linked to human cancers such as lung, breast, and ovarian cancer.
Overexpression of B7-H4 may help tumor cells evade immune surveillance. VTCN1 is also considered a potential biomarker for early detection of ovarian cancer and renal cell carcinoma (RCC).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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