Thermo Fisher Scientific DAXX Polyclonal Antibody
Thermo Fisher Scientific의 DAXX Polyclonal Antibody는 인간 DAXX 단백질을 인식하는 고특이성 항체로 Western blot 및 IHC(Paraffin)에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human DAXX. Recombinant protein control fragment (Product #RP-102461) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789521 |
Product Specific Information
Immunogen sequence:
DEEEEAAAGK DGDKSPMSSL QISNEKNLEP GKQISRSSGE QQNKGRIVSP SLLSEEPLAP SSIDAESNGE QPEELTLEEE SPVSQLFELE IEALPLDTPS SVETDISSSR KQSEEPFTTV LENGAGMVSS TSFNGGVSPH NWGDSG
Target Information
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and cytoplasm. It interacts with various proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1.
In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by sequestration into promyelocytic leukemia nuclear bodies or nucleoli.
It also associates with centromeres in G2 phase and may regulate apoptosis in the cytoplasm. Subcellular localization and function are modulated by post-translational modifications, including sumoylation, phosphorylation, and polyubiquitination.
Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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