Thermo Fisher Scientific Cdc37 Recombinant Rabbit Monoclonal Antibody (10C3)
Cdc37 단백질을 인식하는 토끼 유래 재조합 단클론 항체. Western blot 및 유세포분석에 사용 가능. HEK293 세포에서 발현된 IgG 형 항체로, 고순도의 친화 크로마토그래피 정제. 세포주기 조절 및 HSP90 관련 연구에 적합.
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:5,000 |
| Flow Cytometry (Flow) | 1:20–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 10C3 |
| Immunogen | A synthesized peptide derived from human Cdc37 (aa 9–24) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.12 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 150 mM NaCl |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C or −80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_2898327 |
Product Specific Information
This antibody has been tested in direct-ELISA.
Target Information
In S. cerevisiae, Cdc37 is an important regulator of the cell division cycle through its action on cyclin-dependent kinases (CDKs). It is also associated with signaling pathways and kinases unrelated to cell cycle control, including v-Src, casein kinase II, MPS1 kinase, and the sevenless receptor tyrosine kinase.
HSP90 has been shown to associate with many of the same cellular targets as Cdc37. Cdc37, also known as p50, forms complexes with Src-family kinases (Fyn, Yes, Fes, Lck, and Fgr), Raf, and pp60v-src.
Cdc37 functions as a molecular chaperone independently and in cooperation with HSP90, and is essential for HSP90 binding to Cdk4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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