Thermo Fisher Scientific SARS-CoV-2 Spike Protein (RBD) Chimeric Recombinant Human Monoclonal Antibody (Sb#45)
SARS-CoV-2 스파이크 단백질 RBD를 인식하는 인간 재조합 단클론 항체. ELISA 및 기능적 억제 분석에 적합. HEK293 세포에서 발현된 IgG1 Fc 형 항체로 Protein A로 정제됨. 연구용으로만 사용 가능.
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Applications
- ELISA (ELISA): Assay-dependent
- Functional Assay (Functional): Assay-dependent
- Inhibition Assays (IA): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Virus |
| Host / Isotype | Human / IgG1, Fc |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Sb#45 |
| Immunogen | This clone was originally isolated in a form of a synthetic nanobody (sybody) via a target swap selection procedure against RBD-vYFP using ribosomal display and against RBD-Fc fusion during phage display rounds. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody recognizes and binds the SARS-CoV-2 C-terminal receptor binding domain (RBD) located in the extracellular portion of the spike protein.
Target Information
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), also known as 2019-nCoV (2019 Novel Coronavirus), causes illnesses ranging from mild cold-like symptoms to severe respiratory distress and death.
The CoV Spike (S) protein is crucial for viral attachment, fusion, and entry, and serves as a major target for developing antibodies, entry inhibitors, and vaccines.
The Spike protein receptor-binding domain (RBD, S-RBD) binds strongly to human and bat angiotensin-converting enzyme 2 (ACE2) receptors, showing higher affinity than SARS-CoV RBD.
The S1 subunit contains the RBD that specifically interacts with ACE2 receptors on target cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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