Thermo Fisher Scientific NGF Polyclonal Antibody
NGF 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P) 분석에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 동결건조 형태로 제공되어 안정적입니다. 신경성장 관련 연구에 활용 가능합니다.
- 카탈로그번호
- OSN00109W-100UL
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 | – |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 | – |
| Miscellaneous PubMed (Misc) | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 195–240 of human mature NGF conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C for short term. For long-term storage, keep at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide is homologous in rat and mouse.
- Specificity: Detects mature NGF, not proNGF, in salivary gland at least.
Target Information
Nerve growth factor (NGF) influences the survival and differentiation of various neuronal and non-neuronal cells. NGF binds to specific cell surface receptors with high and low affinity, with only the high-affinity receptor mediating signal transduction. Cross-linking studies with ¹²⁵I-NGF have shown that the high-affinity receptor in rat PC12 cells forms an Mr 158,000 complex with NGF, while the low-affinity receptor forms an Mr 100,000 complex.
Full-length cDNA clones for both human and rat NGF receptor genes show greater than 90% homology. NGF regulates growth and differentiation of sympathetic and sensory neurons, and mutations in the NGF gene are associated with hereditary sensory and autonomic neuropathy type 5 (HSAN5). Dysregulation of NGF expression is linked to allergic rhinitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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