Thermo Fisher Scientific NeuN Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
• The peptide is homologous in mouse and rat.
• Specificity: NeuN.

Target Information

Fox-3, also known as NEUN, HRNBP3, RBFOX3 (RNA binding protein, fox-1) or Fox-1 homolog C, is a 350 amino acid protein containing one RRM (RNA recognition motif) domain.
Localized to both the nucleus and cytoplasm, Fox-3 is suggested to regulate alternative splicing events.
Fox-3 is encoded by a gene located on human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes.
Two key tumor suppressor genes associated with chromosome 17 are p53 and BRCA1.

• p53: Maintains cellular genetic integrity through DNA repair and apoptosis regulation. Malfunction or loss leads to malignant growth and Li-Fraumeni syndrome.
• BRCA1: Involved in DNA repair, recognized as a genetic determinant of early-onset breast cancer and predisposition to ovarian, colon, prostate, and fallopian tube cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.