Thermo Fisher Scientific ABCA4 Monoclonal Antibody (3F4)
ABCA4 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot 및 IHC에 적합합니다. 인간, 소, 생쥐, Xenopus 시료에 반응하며, 단백질 G로 정제된 액상 형태입니다. 시판용이 아닌 연구용으로 -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Immunohistochemistry (IHC)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Xenopus |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3F4 |
| Immunogen | Partially purified bovine 220-kDa disc rim protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | ~1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 10 mM HEPES, pH 7.5, with 100 µg/mL BSA, 50% glycerol, 0.15 M NaCl |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2802645 |
Product Specific Information
Excitation: 405 nm
Emission: 645 nm
Laser: Blue Laser
Target Information
ABCA4 (ATP-Binding Cassette, Subfamily A, Member 4), also known as ABCR, is a protein encoded by the ABCA4 gene in humans. It belongs to the ATP-binding cassette transporter sub-family A (ABC1), found exclusively in multicellular eukaryotes.
This gene maps to chromosome 1p21-p13 and is expressed exclusively in retinal photoreceptor cells, mediating transport of essential molecules across the photoreceptor cell membrane.
Immunofluorescence microscopy and Western blot analyses show ABCR presence in foveal and peripheral cone, as well as rod photoreceptors.
Loss of central vision in Stargardt macular dystrophy patients is linked to ABCR-mediated foveal cone degeneration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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