Thermo Fisher Scientific Angiopoietin 2 VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1255)
Recombinant alpaca monoclonal antibody targeting human Angiopoietin 2 (ANGPT2). Suitable for ELISA applications. Expressed in CHO cells and purified by metal-chelate chromatography. Provided in PBS without preservative and ideal for angiogenesis research.
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- MA554378
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Thermo Fisher Scientific Angiopoietin 2 VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1255)
Applications
- ELISA (Assay-dependent)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Alpaca / VHH |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SAA1255 |
| Immunogen | Recombinant Human ANGPT2 / Ang2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Metal-chelate chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Product Specific Information
- Compatible with Direct ELISA
Target Information
ANG-2 binds to the endothelial cell-specific receptor Tie-2 but, unlike ANG-1, does not induce tyrosine phosphorylation. Consequently, ANG-2 modulates ANG-1 activation of Tie-2 and can act as either an agonist or antagonist of Tie-2-induced angiogenesis depending on the physiological context.
The signaling interactions among ANG-1, ANG-2, and Tie-2, along with ANG-3 and ANG-4, are essential for embryonic and adult angiogenesis.
Physiologically, ANG-1 and ANG-2 are associated with sprouting, tube formation, and the structural integrity of newly formed blood vessels.
Mature human ANG-2 is a secreted protein containing 480 amino acids, composed of an alpha-helix-rich coiled coil N-terminal domain and a fibrinogen-like C-terminal domain, existing predominantly as a disulfide-linked dimer.
Usage Notes
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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