Thermo Fisher Scientific Angiopoietin 2 VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1255)

Thermo Fisher Scientific Angiopoietin 2 VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1255)

Applications

• ELISA (Assay-dependent)

Product Specifications

Product Specific Information

• Compatible with Direct ELISA

Target Information

ANG-2 binds to the endothelial cell-specific receptor Tie-2 but, unlike ANG-1, does not induce tyrosine phosphorylation. Consequently, ANG-2 modulates ANG-1 activation of Tie-2 and can act as either an agonist or antagonist of Tie-2-induced angiogenesis depending on the physiological context.
The signaling interactions among ANG-1, ANG-2, and Tie-2, along with ANG-3 and ANG-4, are essential for embryonic and adult angiogenesis.
Physiologically, ANG-1 and ANG-2 are associated with sprouting, tube formation, and the structural integrity of newly formed blood vessels.
Mature human ANG-2 is a secreted protein containing 480 amino acids, composed of an alpha-helix-rich coiled coil N-terminal domain and a fibrinogen-like C-terminal domain, existing predominantly as a disulfide-linked dimer.

Usage Notes

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.