Thermo Fisher Scientific LOX Recombinant Rabbit Monoclonal Antibody (JU30-23)
LOX 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC, Flow cytometry에 적합합니다. 높은 특이성과 재현성을 제공하며, 다양한 종(인간, 마우스, 랫, 제브라피시)에 반응합니다. 단백질 A로 정제된 액상 형태로 안정적인 저장이 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
| Flow Cytometry (Flow) | 1:1,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat, Zebrafish |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JU30-23 |
| Immunogen | Synthetic peptide within Human LOX aa 368–417 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2810093 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the optimal candidates for production.
Advantages:
- Superior specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
Lysyl oxidase (LOX) is a copper-containing amine oxidase that catalyzes the oxidation of primary amines to reactive aldehydes. It plays a crucial role in extracellular matrix formation and repair. LOX also functions in developmental regulation, tumor suppression, cell motility, and cellular senescence. The secreted form contributes to the invasive properties of hypoxic cancer cells, making LOX a potential therapeutic target for metastasis prevention and treatment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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