Thermo Fisher Scientific Sortilin Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1 µg/mL

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide conjugated to KLH derived from within residues 800 to the C-terminus of Human Sortilin. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Sortilin,uniProtId:Q99523-1,ncbiNodeId:9606,antigenRange:800-831,antigenLength:831,antigenImageFileName:PA5-19481_Sortilin_Q99523-1_Rabbit.svg,antigenImageFileNamePDP:PA5-19481_Sortilin_Q99523-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10986596

Product Specific Information

PA5-19481 targets Sortilin in flow cytometry, immunoprecipitation, immunocytochemistry, immunofluorescence, immunohistochemistry (frozen), and Western blot applications and shows reactivity with Human, mouse, Cow, and Rat samples.

The PA5-19481 immunogen is synthetic peptide conjugated to KLH derived from within residues 800 to the C-terminus of Human Sortilin.

PA5-19481 detects Sortilin which has a predicted molecular weight of approximately ~100 kDa.

Target Information

Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Sortilin is required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). It is also required for protein transport from the Golgi apparatus to the endosomes. Sortilin promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also, Sortilin acts as a receptor for neurotensin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.