Thermo Fisher Scientific E-cadherin Polyclonal Antibody
E-cadherin 단백질을 표적하는 Thermo Fisher Scientific의 rabbit polyclonal antibody. Western blot, IHC, ICC/IF 등 다양한 응용에 적합하며, 인간·마우스·랫트 반응성 확인. 고순도 항원 친화 크로마토그래피로 정제된 액상 형태로 제공.
- 카탈로그번호
- PA519479
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific E-cadherin Polyclonal Antibody
Thermo Fisher Scientific E-cadherin Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | View 2 publications |
| Immunohistochemistry (IHC) | - | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1 µg/mL | View 1 publication |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | View 1 publication |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Avian, Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide conjugated to KLH derived from within residues 850 to the C-terminus of Human pan Cadherin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10988711 |
Product Specific Information
- A diffuse signal may be seen at higher concentrations (5–10 µg/mL) in ICC/IF.
- In Western Blot, non-specific bands at 40 kDa, 65 kDa, 75 kDa, and 90 kDa may appear.
- Predicted to react with chicken, cow, and Xenopus laevis based on sequence homology.
- May not perform well in ICC/IF using mouse cells.
Target Information
E-Cadherin (epithelial cadherin) is a classical cadherin from the calcium-dependent adhesion protein superfamily. It is a calcium-dependent cell–cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail. Mutations in this gene are associated with gastric, breast, colorectal, thyroid, and ovarian cancers. Loss of function contributes to cancer progression by enhancing proliferation, invasion, and metastasis. The ectodomain mediates bacterial adhesion to mammalian cells, while the cytoplasmic domain is required for internalization. E-cadherin plays a central role in tissue architecture and integrity. In humans, it is encoded by the CDH1 gene on chromosome 16. Reduced or lost expression correlates with increased tumor invasiveness and metastatic potential.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
- PA5-19479_E-cadherin_P12830-1_Rabbit.svg
- PA5-19479_E-cadherin_P12830-1_Rabbit_PDP.jpeg
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.