Thermo Fisher Scientific Phospho-PSD-95 (Thr19) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested dilution: 1 µg/mL

Product Specifications

Product Specific Information

This antibody is predicted to react with rat and human based on sequence homology.

Target Information

Post Synaptic Density 95 kDa (PSD-95), also known as synapse associated protein 90 kDa (SAP90), is a membrane-associated protein found in the postsynaptic density of forebrain neurons and certain presynaptic structures in the cerebellum.
PSD-95 contains three PDZ domains, one SH3 domain, and one guanylate kinase homology (GuK) domain. It plays a key role in clustering NMDA receptors and Shaker-type potassium channels at the synaptic membrane in CNS neurons.

PSD-95 interacts with other proteins through:

1. C-terminal T/SXV motifs shared by NMDA receptors and potassium channels.
2. PDZ-PDZ interactions, such as with neuronal nitric oxide synthase (nNOS).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.