Thermo Fisher Scientific Phospho-PSD-95 (Thr19) Polyclonal Antibody
Rabbit polyclonal antibody specific for phosphorylated PSD-95 (Thr19). Validated for Western blot at 1 µg/mL. Predicted to react with rat and human. Supplied as a liquid, 0.3 mg/mL, for research use only.
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Applications
Western Blot (WB)
- Tested dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide conjugated to KLH derived from within residues 1–100 of Mouse PSD95, phosphorylated at T19 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Storage conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10988442 |
Product Specific Information
This antibody is predicted to react with rat and human based on sequence homology.
Target Information
Post Synaptic Density 95 kDa (PSD-95), also known as synapse associated protein 90 kDa (SAP90), is a membrane-associated protein found in the postsynaptic density of forebrain neurons and certain presynaptic structures in the cerebellum.
PSD-95 contains three PDZ domains, one SH3 domain, and one guanylate kinase homology (GuK) domain. It plays a key role in clustering NMDA receptors and Shaker-type potassium channels at the synaptic membrane in CNS neurons.
PSD-95 interacts with other proteins through:
- C-terminal T/SXV motifs shared by NMDA receptors and potassium channels.
- PDZ-PDZ interactions, such as with neuronal nitric oxide synthase (nNOS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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