Thermo Fisher Scientific PKC theta Polyclonal Antibody
PKC theta 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC(Paraffin) 분석에 적합합니다. Human, Mouse, Rat 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 4°C 단기 보관, -20°C 장기 보관 권장.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 520–570 of Human PKC theta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2803322 |
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
Protein Kinase C (PKC) isoforms are serine/threonine kinases involved in signal transduction pathways that govern a wide range of physiological processes including differentiation, proliferation, gene expression, brain function, membrane transport, and the organization of cytoskeletal and extracellular matrix proteins.
PKC acts as a key regulator of critical cell cycle transitions, including cell cycle entry and exit and the G1 and G2 checkpoints. The effect of PKC-mediated control can be positive or negative depending on activation timing and isozyme type.
At least 12 PKC isoforms have been identified in humans (α, βI, βII, γ, δ, ε, ζ, η, θ, ι, λ, μ), differing in structure, localization, tissue distribution, and response to extracellular signals. PKC βII is expressed in cardiac muscle, intestinal epithelium, kidney, and pancreas, and is associated with cell cycle progression and cancer proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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