Thermo Fisher Scientific RHBDD3 Polyclonal Antibody
RHBDD3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간, 마우스, 랫트 반응성. WB 및 IHC에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 항체로, 2–8°C 보관. 연구용 전용 제품.
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Thermo Fisher Scientific RHBDD3 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (IHC) | 20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 13 amino acid peptide from near the center of human RHBDD3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11157850 |
Product Specific Information
- Suggested positive control: rat lung tissue lysate
- PA5-20862 can be used with blocking peptide PEP-0976
Target Information
The Rhomboid family of proteins comprises several widely conserved polytopic membrane serine proteases involved in growth and development.
RHBDD3 was first identified as a novel pituitary tumor apoptosis gene (PTAG) with reduced expression in certain pituitary adenomas.
Overexpression of RHBDD3 in AtT20 cells increased apoptotic activity and caspase activation in response to bromocriptine, suggesting that reactivation of RHBDD3 in tumors may have therapeutic potential.
Further studies showed reduced RHBDD3 expression in several primary colorectal tumors, indicating that loss of RHBDD3 contributes to diminished apoptotic response and may predispose cells to malignant transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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