Thermo Fisher Scientific PODN Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is >95% (by SDS-PAGE).

Target Information

Non-collagenous proteins of the small leucine-rich repeat (SLR) protein family are important components of the extracellular matrix. The extracellular matrix regulates development, tissue repair, and metastasis through cell proliferation, differentiation, adhesion, and migration.

Podocan (also known as PCAN, SLRR5A, or PODN) is a 613 amino acid secreted protein belonging to the small leucine-rich proteoglycan (SLRP) family, class V subfamily. It is expressed in kidney, heart, liver, pancreas, and vascular smooth muscle cells. Podocan exists as three alternatively spliced isoforms containing twenty LRRs, a unique N-terminal cysteine-rich cluster, and a highly acidic C-terminal domain. It is a glycoprotein with N-linked oligosaccharides that may regulate growth in cardiovascular tissues. The gene encoding Podocan is located on human chromosome 1 and interacts with type I collagen (COL1).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.