Thermo Fisher Scientific ATXN7L2 Polyclonal Antibody

Thermo Fisher Scientific ATXN7L2 Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1:500–1:1,000

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as confirmed by SDS-PAGE.

Target Information

SCA7 is an autosomal dominant neurodegenerative disorder characterized by ataxia and selective neuronal cell loss caused by the expansion of a translated CAG repeat encoding a polyglutamine tract in ataxin-7, which is the SCA7 gene product.
Ataxin-7 is a nuclear protein expressed within neurons both affected and unaffected in SCA7 pathology, with variable subcellular localization depending on neuronal subtype.
Polyglutamine expansion in ataxin-7 may exert pathogenic effects in the nucleus by altering matrix-associated nuclear structure and/or disrupting nucleolar function.
ATXN7L2 (Ataxin-7-like protein 2) is a 722 amino acid protein containing a SCA7 domain, highly conserved among ATXN7 family members. The gene encoding ATXN7L2 maps to human chromosome 1, which spans approximately 260 million base pairs and represents about 8% of the human genome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.