Thermo Fisher Scientific Phospho-CtIP (Ser664) Polyclonal Antibody
CtIP 단백질의 Ser664 인산화 상태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot과 IHC(Paraffin)에서 검증됨. Human, Mouse, Rat 반응성. PBS buffer와 50% glycerol에 보관되며 -20°C 저장. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RBBP8 (Accession Q99708), corresponding to amino acid residues around phosphorylated Ser664 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817231 |
Product Specific Information
Antibody detects endogenous levels of CtIP only when phosphorylated at Ser664.
Target Information
CtIP, a 125 kD protein, was originally found interacting with a transcription repressor, CtBP, through the PLDLS motif (CtBP-Interacting Protein), suggesting a role in transcription. Studies have shown that CtIP also interacts with BRCA1 protein through the C-terminus BRCT domains, indicating that CtIP is a potential tumor suppressor. This CtIP–BRCA1 interaction can be disrupted by DNA-damaging agents including UV or gamma irradiation.
Li et al. (Nature 406, 210–215 (2000)) demonstrated that ATM phosphorylates CtIP at serine residues 664 and 745, and mutation of these sites abrogates BRCA1 dissociation from CtIP, resulting in persistent repression of BRCA1-dependent induction of GADD45 upon ionizing radiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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