Thermo Fisher Scientific CD80 (B7-1) Monoclonal Antibody (16-10A1), Alexa Fluor 700, eBioscience
마우스 CD80(B7-1) 항원을 인식하는 16-10A1 클론 단일클론 항체로, Alexa Fluor 700 형광체가 결합되어 있습니다. Flow cytometry에 최적화되어 있으며, 0.25 µg/test로 사용 가능합니다. 면역세포 활성화 연구 및 T-B 세포 상호작용 분석에 유용합니다.
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Thermo Fisher Scientific CD80 (B7-1) Monoclonal Antibody (16-10A1), Alexa Fluor 700, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Flow Cytometry (Flow) | 0.25 µg/test | View 41 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Mouse, Pig |
| Published Species | Not Applicable |
| Host / Isotype | Armenian hamster / IgG |
| Recommended Isotype Control | Armenian Hamster IgG Isotype Control (eBio299Arm), Alexa Fluor™ 700, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 16-10A1 |
| Conjugate | Alexa Fluor™ 700 |
| Excitation / Emission Max | 696 / 719 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2815244 |
Available Formats
- Unconjugated
- APC
- Biotin
- Brilliant UV 615
- Brilliant UV 737
- Brilliant Violet 480
- Brilliant Violet 605
- Brilliant Violet 711
- Brilliant Violet 786
- eFluor 450
- FITC
- Functional Grade
- PE
- PE-Cyanine5
- PE-Cyanine7
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 645
- Request custom conjugation
Product Specific Information
The 16-10A1 monoclonal antibody reacts with mouse CD80 (B7-1), a 55 kDa member of the Ig superfamily. CD80 is expressed by macrophages, dendritic cells, activated B cells, and activated T cells. It binds with high affinity to CD28 and CD152 (CTLA-4), which are crucial for T-B cell communication and activation.
- Applications Reported: Flow cytometric analysis
- Applications Tested: Tested on stimulated mouse splenocytes; ≤ 0.25 µg/test
- Excitation/Emission: 633–647 nm / 723 nm (Red Laser)
- Recommended Filters: 685 LP mirror and 710/20 band pass filter
Ensure instrument compatibility with Alexa Fluor 700 detection.
Target Information
CD80 (B7-1) and CD86 (B7-2) are ligands of T cell costimulatory molecule CD28 and inhibitory receptor CTLA-4 (CD152). Both are expressed on professional antigen-presenting cells and are essential for T cell activation.
CD80 is rapidly induced on activated B cells and is found in EBV-transformed B cell lines, Burkitt’s lymphoma cells, follicular B lymphoma, T cells, and monocytes.
CD80 dysfunction has been associated with diseases such as gallbladder squamous cell carcinoma and myocarditis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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